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Furthermore, Li et al. have discovered that the upregulation of PI3K/AKT pathway encourages the expressions of placental development component (PlGF) and C-X-C Motif Chemokine Ligand 1 (CXCL1) in lung most cancers stem cells, which even further promote angiogenesis [59]. CCPlenty of paracrine aspects secreted by MSCs are ligands for receptors that
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